Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues. Commentary
Identifieur interne : 008E76 ( Main/Exploration ); précédent : 008E75; suivant : 008E77Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues. Commentary
Auteurs : Mervin C. Yoder [États-Unis] ; Vanta J. Jokubaitis [Australie] ; Lidia Sinka [France] ; Rebecca Driessen [Australie] ; Genevieve Whitty [Australie] ; David N. Haylock [Australie] ; Ivan Bertoncello [Australie] ; Lan Smith [Australie] ; Bruno Peault [États-Unis] ; Manuela Tavian [France] ; Paul J. Simmons [Australie, États-Unis]Source :
- Blood [ 0006-4971 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Cellule souche, Homme, Adulte.
English descriptors
- KwdEn :
Abstract
Previous studies revealed that mAb BB9 reacts with a subset of CD34+ human BM cells with hematopoietic stem cell (HSC) characteristics. Here we map BB9 expression throughout hematopoietic development and show that the earliest definitive HSCs that arise at the ventral wall of the aorta and surrounding endothelial cells are BB9+. Thereafter, BB9 is expressed by primitive hematopoietic cells in fetal liver and in umbilical cord blood (UCB). BB9+CD34+ UCB cells transplanted into nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice contribute 10-fold higher numbers of multilin-eage blood cells than their CD34+BB9- counterparts and contain a significantly higher incidence of SCID-repopulating cells than the unfractionated CD34+ population. Protein microsequencing of the 160-kDa band corresponding to the BB9 protein established its identity as that of somatic angiotensin-converting enzyme (ACE). Although the role of ACE on human HSCs remains to be determined, these studies designate ACE as a hitherto unrecognized marker of human HSCs throughout hematopoietic ontogeny and adulthood.
Affiliations:
- Australie, France, États-Unis
- Victoria (État), Île-de-France
- Melbourne, Orsay
- Université Paris-Sud, Université de Melbourne
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Simmons</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Stem Cell Biology Laboratory, Peter MacCallum Cancer Centre</s1><s2>East Melbourne</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>East Melbourne</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Brown Foundation Institute of Molecular Medicine (IMM), University of Texas Health Science Center</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, TX</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0314288</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0314288 INIST</idno><idno type="RBID">Pascal:08-0314288</idno><idno type="wicri:Area/PascalFrancis/Corpus">003462</idno><idno type="wicri:Area/PascalFrancis/Curation">002B87</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">003409</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">003409</idno><idno type="wicri:doubleKey">0006-4971:2008:Yoder M:angiotensin:converting:enzyme</idno><idno type="wicri:Area/Main/Merge">009823</idno><idno type="wicri:Area/Main/Curation">008E76</idno><idno type="wicri:Area/Main/Exploration">008E76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues. Commentary</title><author><name sortKey="Yoder, Mervin C" sort="Yoder, Mervin C" uniqKey="Yoder M" first="Mervin C." last="Yoder">Mervin C. Yoder</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INDIANA UNIVERSITY SCHOOL OF MEDICINE</s1><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>INDIANA UNIVERSITY SCHOOL OF MEDICINE</wicri:noRegion></affiliation></author><author><name sortKey="Jokubaitis, Vanta J" sort="Jokubaitis, Vanta J" uniqKey="Jokubaitis V" first="Vanta J." last="Jokubaitis">Vanta J. Jokubaitis</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Stem Cell Biology Laboratory, Peter MacCallum Cancer Centre</s1><s2>East Melbourne</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>East Melbourne</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Biochemistry and Molecular Biology, University of Melbourne</s1><s2>Parkville</s2><s3>AUS</s3><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Sinka, Lidia" sort="Sinka, Lidia" uniqKey="Sinka L" first="Lidia" last="Sinka">Lidia Sinka</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Inserm U602</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Inserm U602</wicri:noRegion><wicri:noRegion>Inserm U602</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Universite Paris-Sud, Faculte de Medecine</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Faculte de Medecine</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Driessen, Rebecca" sort="Driessen, Rebecca" uniqKey="Driessen R" first="Rebecca" last="Driessen">Rebecca Driessen</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Stem Cell Biology Laboratory, Peter MacCallum Cancer Centre</s1><s2>East Melbourne</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>East Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Whitty, Genevieve" sort="Whitty, Genevieve" uniqKey="Whitty G" first="Genevieve" last="Whitty">Genevieve Whitty</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Australian Stem Cell Centre</s1><s2>Clayton</s2><s3>AUS</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Australian Stem Cell Centre</wicri:noRegion></affiliation></author><author><name sortKey="Haylock, David N" sort="Haylock, David N" uniqKey="Haylock D" first="David N." last="Haylock">David N. Haylock</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Australian Stem Cell Centre</s1><s2>Clayton</s2><s3>AUS</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Australian Stem Cell Centre</wicri:noRegion></affiliation></author><author><name sortKey="Bertoncello, Ivan" sort="Bertoncello, Ivan" uniqKey="Bertoncello I" first="Ivan" last="Bertoncello">Ivan Bertoncello</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Australian Stem Cell Centre</s1><s2>Clayton</s2><s3>AUS</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Australian Stem Cell Centre</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Lan" sort="Smith, Lan" uniqKey="Smith L" first="Lan" last="Smith">Lan Smith</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Baker Institute</s1><s2>Prahran</s2><s3>AUS</s3><sZ>8 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Baker Institute</wicri:noRegion></affiliation></author><author><name sortKey="Peault, Bruno" sort="Peault, Bruno" uniqKey="Peault B" first="Bruno" last="Peault">Bruno Peault</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Rangos Research Center, Children's Hospital</s1><s2>Pittsburgh, PA</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Pittsburgh, PA</wicri:noRegion></affiliation></author><author><name sortKey="Tavian, Manuela" sort="Tavian, Manuela" uniqKey="Tavian M" first="Manuela" last="Tavian">Manuela Tavian</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Inserm U602</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Inserm U602</wicri:noRegion><wicri:noRegion>Inserm U602</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Universite Paris-Sud, Faculte de Medecine</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Faculte de Medecine</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Simmons, Paul J" sort="Simmons, Paul J" uniqKey="Simmons P" first="Paul J." last="Simmons">Paul J. Simmons</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Stem Cell Biology Laboratory, Peter MacCallum Cancer Centre</s1><s2>East Melbourne</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>East Melbourne</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Brown Foundation Institute of Molecular Medicine (IMM), University of Texas Health Science Center</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, TX</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Blood</title><title level="j" type="abbreviated">Blood</title><idno type="ISSN">0006-4971</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Blood</title><title level="j" type="abbreviated">Blood</title><idno type="ISSN">0006-4971</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Embryonic cell</term><term>Fetal cell</term><term>Hematology</term><term>Hematopoietic cell</term><term>Hematopoietic tissue</term><term>Human</term><term>Peptidyl-dipeptidase A</term><term>Stem cell</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Peptidyl-dipeptidase A</term><term>Cellule hématopoïétique</term><term>Cellule souche</term><term>Cellule embryonnaire</term><term>Cellule foetale</term><term>Homme</term><term>Adulte</term><term>Tissu hématopoïétique</term><term>Hématologie</term><term>Angiotensin converting enzyme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cellule souche</term><term>Homme</term><term>Adulte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies revealed that mAb BB9 reacts with a subset of CD34<sup>+</sup> human BM cells with hematopoietic stem cell (HSC) characteristics. Here we map BB9 expression throughout hematopoietic development and show that the earliest definitive HSCs that arise at the ventral wall of the aorta and surrounding endothelial cells are BB9<sup>+</sup>. Thereafter, BB9 is expressed by primitive hematopoietic cells in fetal liver and in umbilical cord blood (UCB). BB9<sup>+</sup>CD34<sup>+</sup> UCB cells transplanted into nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice contribute 10-fold higher numbers of multilin-eage blood cells than their CD34<sup>+</sup>BB9<sup>-</sup> counterparts and contain a significantly higher incidence of SCID-repopulating cells than the unfractionated CD34<sup>+</sup> population. Protein microsequencing of the 160-kDa band corresponding to the BB9 protein established its identity as that of somatic angiotensin-converting enzyme (ACE). Although the role of ACE on human HSCs remains to be determined, these studies designate ACE as a hitherto unrecognized marker of human HSCs throughout hematopoietic ontogeny and adulthood.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>États-Unis</li></country><region><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Melbourne</li><li>Orsay</li></settlement><orgName><li>Université Paris-Sud</li><li>Université de Melbourne</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Yoder, Mervin C" sort="Yoder, Mervin C" uniqKey="Yoder M" first="Mervin C." last="Yoder">Mervin C. Yoder</name></noRegion><name sortKey="Peault, Bruno" sort="Peault, Bruno" uniqKey="Peault B" first="Bruno" last="Peault">Bruno Peault</name><name sortKey="Simmons, Paul J" sort="Simmons, Paul J" uniqKey="Simmons P" first="Paul J." last="Simmons">Paul J. Simmons</name></country><country name="Australie"><noRegion><name sortKey="Jokubaitis, Vanta J" sort="Jokubaitis, Vanta J" uniqKey="Jokubaitis V" first="Vanta J." last="Jokubaitis">Vanta J. Jokubaitis</name></noRegion><name sortKey="Bertoncello, Ivan" sort="Bertoncello, Ivan" uniqKey="Bertoncello I" first="Ivan" last="Bertoncello">Ivan Bertoncello</name><name sortKey="Driessen, Rebecca" sort="Driessen, Rebecca" uniqKey="Driessen R" first="Rebecca" last="Driessen">Rebecca Driessen</name><name sortKey="Haylock, David N" sort="Haylock, David N" uniqKey="Haylock D" first="David N." last="Haylock">David N. Haylock</name><name sortKey="Jokubaitis, Vanta J" sort="Jokubaitis, Vanta J" uniqKey="Jokubaitis V" first="Vanta J." last="Jokubaitis">Vanta J. Jokubaitis</name><name sortKey="Simmons, Paul J" sort="Simmons, Paul J" uniqKey="Simmons P" first="Paul J." last="Simmons">Paul J. Simmons</name><name sortKey="Smith, Lan" sort="Smith, Lan" uniqKey="Smith L" first="Lan" last="Smith">Lan Smith</name><name sortKey="Whitty, Genevieve" sort="Whitty, Genevieve" uniqKey="Whitty G" first="Genevieve" last="Whitty">Genevieve Whitty</name></country><country name="France"><noRegion><name sortKey="Sinka, Lidia" sort="Sinka, Lidia" uniqKey="Sinka L" first="Lidia" last="Sinka">Lidia Sinka</name></noRegion><name sortKey="Sinka, Lidia" sort="Sinka, Lidia" uniqKey="Sinka L" first="Lidia" last="Sinka">Lidia Sinka</name><name sortKey="Tavian, Manuela" sort="Tavian, Manuela" uniqKey="Tavian M" first="Manuela" last="Tavian">Manuela Tavian</name><name sortKey="Tavian, Manuela" sort="Tavian, Manuela" uniqKey="Tavian M" first="Manuela" last="Tavian">Manuela Tavian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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